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CNCS B+ Category Journal
CME Credits: 10 (Romanian College of Physicians)
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Str. Avram Iancu Nr. 1, Sect. 2
Bucuresti, Romania

Current issue

Nr. 2/2015, Vol. 22

A New Step

in Sharing Medical Experience

Medicina ModernĂ£

New Series

Cardiovascular Autonomic Dysfunction: A Possible Prognostic Marker in Patients with Arterial Pulmonary Hypertension

Alexandru Ioan Deaconu, Silvia Iancovici, Diana Zamfir, Tudor Constatinescu, Claudia Toma, Dragoş Zaharia, Miron Bogdan, Maria Dorobanţu

Objectives of the study:We evaluated the prevalence of cardiac autonomic neuropathy (CAN) and its potential as a prognostic marker in patients with right heart failure secondary to pulmonary arterial hypertension (PAH) in a pilot study. Furthermore, we investigated its correlation with the clinical status and a series of paraclinical parameters, and prognostic implications of this association.
Methodology: 17 consecutive patients with PAH were evaluated in our study. The evaluation of CAN was realized by Holter ECG/24h monitoring with heart rate turbulence (HRT) and heart rate variability (HRV) analysis in time and frequency dom…[more...]

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Long-terme Evaluation of Primary Syndactyly Treatment in Children, Using a Flatt Modified Technique

Doina-Iulia Nacea, D.M Enescu, Simona Stoicescu

Objectives: The aim of the present study was to evaluate the results of web reconstruction in children with primary syndactyly, using the technique of Flatt modified by Upton for syndactyly release.
Materials and methods: We reviewed 72 webs in 27 hands and 21 feet in 24 patients, operated for primary syndactyly, during the period of 2002-2013 in the Plastic Surgery and Burns Department of “Grigore Alexandrescu ” Clinical Emergency Hospital for Children. All the webs were corrected by the same surgeon, using the same indication, timing and technique. Skin grafts becoming loose, flap necrosis, development of local infection, web…[more...]

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Botulinum Toxin Type A – Possible Anti-Nociceptive Effect on Mice

Elena-Rodica Dragu, Bogdan Liviu Chioaru, Ioana Teona Sebe, Ioan Lascăr, Oana Andreia Coman,

Botulinum toxin, originally used in the treatment of spastic neuromuscular diseases, received increased attention in recent decades and a deeper research, further mechanisms of action being carefully studied in order to determine other possible therapeutic properties.
Method and material: This is an experimental study conducted on 60 CD1 mice, divided into 4 groups of 15 each, injected with saline solution and 3 different doses of type A botulinum toxin.
Objectives: Our study aims to establish an anti-nociceptive properties of botulinum toxin, dose-dependent, remote from the injection site.
Results: We could observe possi…[more...]

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Experimental Research on the Interactions between Selective COX-2 Inhibitors and Antidepressants

Horia Păunescu

Objectives: The Porsolt test and the tail suspension test were performed on mice to investigate possible mood effects of parecoxib, and to assess the interactions between this agent and antidepressants belonging to two different classes.
Materials and methods: In the Porsolt test, parecoxib was given in geometric progression doses (ratio 2), in order to assess the epressant antidepressant effect, then parecoxib was given in the dose of 40 mg kg body weight (bw), either alone or in association with amitriptyline 5 mg kg bw in both tests, and in association with fluoxetine 10 mg kg bw in the Porsolt test, respectively.

Results: P…[more...]

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Nutritional Impact on Cardiovascular Risk in Chronic Hemodialysed Patients – A Systematic Review

Andra E. Balcangiu-Stroescu, Ileana Peride, Ileana Adela Văcăroiu,
Ionel Alexandru Checheriţă, Andrei Niculae

Advanced stage chronic kidney disease (CKD) and chronic hemodialysis are two clinical entities associated with increased cardiovascular risk and thus with elevated mortality.
This causal relationship is largely due to bioumoral changes occurring in the disease evolution. CKD leads to protein-energy malnutrition, mineral and bone related disorders. These features are partially determining cardiovascular risk in chronic hemodialysis patients….[more...]

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