The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

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Modern Diagnostic Approach of Acute Lymphoblastic Leukemia in Children and Adolescents...

2015-04

Modern Diagnostic Approach of Acute Lymphoblastic Leukemia in Children and Adolescents - Experience of a Single Pediatric Hematology-Oncology Center

Claudia Dita, Anca Colita, Mirela Asan, Anca Gheorghe, Constantin Arion

Acute lymphoblastic leukemia (ALL) is the most frequent malignancy in children, representing 25% of all the neoplastic diseases in people younger than 15 years [1].

The peak of incidence is between ages 2 and 3 years [1]. In adolescents (15 to 19 years), ALL comprises only 7% of all cancers [2]. In the United States, it is estimated that 2500 - 3500 children are diagnosed with ALL every year [1]. The incidence appears to be increasing. In Europe it was reported a 1.4% increase in incidence from 1970 to 1999 [3].

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