The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

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Atypical Lipomatous Tumor/Well Differentiated Liposarcoma: a Borderline Malignancy Tumor

2016-04

Cornelia Nitipir, Florin Andrei, Dragos Zamfirescu, Florina Vasilescu, Dana Terzea, Irina Radu, Maria Alexandra Barbu, Bogdan Popescu

Adipocytic tumors represent the largest single group of mesenchymal tumors, due to the high prevalence of lipomas and angiolipomas. Liposarcomas are histologically divided into five subtypes: myxoid, pleomorphic, dedifferentiated, round cell and atypical lipomatous tumor (well-differentiated liposarcoma). Atypical li-pomatous tumor (ALT) is the most common histological subgroup, they account for 40% to 45% of all liposarcomas. Well-diff erentiated (WD) liposarco-mas are locally aggressive but incapable of metastasis. Approximately 75% develop in the deep soft tissue of the limbs, followed by 20% in the retroperitoneum and a much smaller percentage in the inguinal region and the mediastinum. They are usually diagnosed after the fifth decade of life, with a slight male predominance re-ported. Atypical lipomatous tumor is an intermediate (locally aggressive) neoplasm composed either entirely or in part of a mature adipocytic proliferation showing significant variation in cell size, atypical stromal cells and a limited number of scattered monovacuolated or multivacuolated lipoblasts. [...]

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