The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

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The Role of Histamine and Serotonin in the Control of Vascular Motricity of the Anterior Ocular Segment - Review of..

2018-01

The Role of Histamine and Serotonin in the Control of Vascular Motricity of the Anterior Ocular Segment - Review of the Literature from 1997 to 2018

Dragos-Constantin Lunca, Horia Paunescu, Laurentiu Coman, Ion Fulga

https://doi.org/10.31689/rmm.2018.25.1.6

Histamine and serotonin (5-hydroxytryptamine) are two amino acid derivatives with important biological functions [1]. Histamine, an endogenous monoamine, is synthesized from the histidine and is stored in most tissues and degraded in liver by histaminase. The most important roles of histamine are: mediation of type I allergic reactions, stimulation of stomach secretion of hydrochloric acid and pepsin (as autacoid), and functioning as a neurotransmitter (especially in the central nervous system)[2]. Regarding the vascular effects of histamine in non-ocular territories, there have not been many published literature reviews, for example, there are data reviewed for pulmonary artery[3], brain territory[4], but these data are not recent.

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