The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

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Friday, April 27 2018 @ 06:03 EEST

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Multiple Benefic Effects of the Systemic Exposure to the Hydroxychloroquine Sulfate

2014-03

Aida (Pancă) Geamănu, Alina Popa-Cherecheanu, B. Marinescu, D.C. Geamănu, Liliana Voinea

In the twentieth century, the widespread use of quinacrine by the U.S. military as malaria prophylaxis was accompanied by other observations suggesting efficacy for treatment of rheumatologic diseases [1].

During the 1950s, the hydroxychloroquine (HCQ) derivative of quinacrine showed a favorable usage profile with less eye toxicity than chloroquine itself, and the use of this agent in the treatment of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) has become common. In RA, HCQ is usually a component of a drug combination, including triple drug therapy with methotrexate and sulfasalazine, a formula which was claimed as a safe alternative, well tolerated compared to expensive biological therapies [2].

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HYPONATREMIA IN PREDIALYSIS HOSPITALIZED PATIENTS: AN UPDATE ON CLINICAL DATA AND MANAGEMENT

2014-03

Alice Bălăceanu, I.A. Checheriță, A. Niculae, Ileana Peride, Camelia Diaconu, Gheorghița Aron

Hyponatremia, with an incidence of 15 - 22%, is considered when serum sodium levels are < 135 mEq/L (in institutionalized geriatric patients, in 1 - 4% to 7 - 53% cases there have been reported values below 130 mEq/L) [1-3]. Additionally, according to expert panel recommendations the frequency of hyponatremia in hospitalized patients depends on the detected level of hyponatremia [2]. This special condition is highly important to be detected on time because it represents a recognized risk factor of morbidity and mortality, even in asymptomatic patients [1]. Furthermore, it was noticed that a swift correction can induce severe neurological disorders and even death [1]. Therefore, for an adequate treatment management (prophylaxis and therapy) is vital for understanding hyponatremia main causes and the incriminated pathophysiological mechanisms [1].

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PERFORATORS OF THE CALF ARTERIES - ANATOMICAL STUDY

2014-03

Crenguța Coman, D.M. Enescu, Iulia Iacob, S. Dumitrache, C. Bejinariu, Carmen Giuglea

In reconstructive surgery, perforator flaps have a short history. Not more than 27 years ago, Nakajima et al. described the six types of perforator vessels known at present: direct cutaneous, direct septocutaneous, direct cutaneous branch of muscular vessel, perforating cutaneous branch of muscular vessel, septocutaneous perforator and musculo-cutaneous perforator [1]. (Fig. 1)

The knowledge about these perforator vessels continuously grew, by identifying the vascular networks of the entire body, formed by the perforator vessels. Therefore, it became possible to create a lot of perforator flaps based on these perforator vessels [2]. Thus, perforator flaps can be considered the latest milestone in the evolution of reconstructive flap surgery. Many methods are used for investigating the exact location of the perforators, such as imaging methods: computed tomography, magnetic resonance angiography and lately thermal imaging that became also reliable [3]. The exact knowledge of the location and caliber of perforators became a real help for plastic surgeons, especially in the calf area, where the reconstructive method has to accomplish the functional and aesthetic needs for both reconstructed and donor areas.

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Study Regarding the Distribution and Degree of Dysplasia of Colonic Polyps

2014-03

M. Ifrim, C. Toth, C. Precup

There are worldwide standardization attempts, through therapeutic guidelines of colon cancer screenings. For a screening to be effective, it must involve a more complex understanding of risk factors, finding effective methods and most importantly to applied en masse at an acceptable cost.

In this study I tried to present the situation regarding colon cancer screening in at risk patients in Arad county.

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Split-thickness Skin Grafting in the Treatment of Surgically Operated Diabetic Foot. A Retrospective 2-Year Study (2010-2011)

2014-03

Mihaela Vilcu, E. Catrina, T. Pătrașcu, Z. Filipovski, I. Brezean

Diabetes mellitus is a major health problem with significant impact on the quality of life, due to both its complications and comorbidities and due to the costs it generates. There is widespread agreement that the incidence of the disease has increased over the last years, both due to better population monitoring and improvements in diagnosing methods.

Thus, the number of cases of diabetes mellitus worldwide was 382 million in 2013 and the number is rising; there are 75 million cases of diabetes mellitus which go undiagnosed, as the majority of diabetic patients are discovered only when complications set in. (1)

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