The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

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Friday, August 18 2017 @ 05:30 EEST

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A Retrospective Forensic Study in Head Trauma Patients with Undiagnosed Skull Fractures at Computerised Tomography (CT) Scans

2017-01

Roxana-Maria Duncea, Relu-George Calota, Alec Cosmin Moldovan, Vladimir Belis

Computerized tomography (CT) scan is the primary screening modality of investigations in head trauma victims[1]. Since 1971 when it was invented, CT scan has advanced significantly from time-intensive single-section scanning to multi-detector row CT[2]. Nowadays, rapid and accurate assessment of injuries in emergency departments is based on CT scans. Th ere is a high degree of difficulty in terms of causal link, between the injury and the death causing mechanism in patients, with multiple affections and head trauma[3]. [...]

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The Effect of Allopurinol on Endothelial Function, Serum Uric Acid and NT-proBNP in Acute Decompensated Heart Failure

2017-01

Madalina Sorina Ababei, Alexandru Campeanu, Diana Cornelia Nistorescu, Ondin Zaharia, Gabriela Gheorghe, Ileana Peride, Andrei Niculae, Ioan Tiberiu Nanea

Acute decompensated heart failure has an increasing incidence and poor prognosis, being a major cause of death and hospital readmission and requiring urgent optimized therapy[1]. Under the influence of some decompensation risk factor, such as infections, arrhythmias, decompensation of some comorbidities, lack of adherence to the treatment, patients with a history of heart failure may suffer a progressive symptomatology worsening; therefore, more than 70% of cases of acute heart failure represent the clinical worsening of chronic heart failure - ADHF[2]. [...]

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Contrast Enhanced Ultrasonography in Diagnosis of Hypertensive Nephrosclerosis

2017-01

Liliana Albusoiu, Alexandru Campeanu, Marina Budau, Viorel Jinga, Ileana Peride, Andrei Niculae, Cristiana David, Ioan Tiberiu Nanea

The link between kidney damage and HT remains a challenge in medical research from a century when HT concept was defined, taking in consideration than HT is a major risk factor for cardiovascular disease morta-lity worldwide, due to the increasing prevalence, poor compliance to treatment and many complications[1-3]. The hypertensive nephrosclerosis is currently diagnosed in the latest stages of the disease because, for a long period of time, the injuries are compensated by kidney and therefore the clinical presentation is not specific[4]. The current diagnostic methods are non-specific, especially for early diagnosis of hypertensive nephrosclerosis, except the renal biopsy which is considered the gold standard but is rarely indicated in clinical routine due to its invasiveness and possible severe complications[5]. The pathogenic mechanism is complex and not very well understood but renal microcirculation impairment seems to be responsible for the onset and progression of this disease[6]. Therefore, any method that can accurately assess the early microvasculature changes of renal cortex, easy to use, simple and safe, with no invasiveness, could be an important diagnostic tool in hypertensive nephrosclerosis approach. [...]

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Pharmacodynamics of Serotonin. Emphasis on 5HT-3 Antagonists and SSRI Medication (II)

2017-01

Mihnea Costescu, Horia Paunescu, Sorina Vasile, Aurelian Zugravu, Oana Andreia Coman, Ion Fulga

5-HT4 receptors are a G-protein-coupled family of re-ceptors coupled with Gs protein that stimulates the pro-duction of the intracellular signaling molecule cAMP. It has two isoforms (5-HT4S and 5-HT4L), differing in the length and sequence of their C-termini[1]. 5-HT4 are present both in the central nervous system and peripheral tissues; in the brain, are found mostly in basal ganglia and the hippocampus[2]. In the periphery, 5HT4 play an important role in the functioning of gastrointestinal tract, urinary bladder, heart and adrenal gland. Gastrointestinal 5-HT4 receptors potentiate peristalsis, and electrolyte secretion. In the urinary bladder, acti-vation of 5-HT4 receptors modulates cholinergic and purinergic transmission. Stimulation of atrial 5-HT4 receptors produces tachycardia and arrhythmias. In the adrenal gland, activation of 5-HT4 receptors releases cortisol, aldosterone and corticosterone[3]. [...]

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HPV and Bladder Cancer - Is There a Connection?

2017-01

Dan Arsenie Spinu, Ovidiu Gabriel Bratu, Dragos Radu Marcu, Andrei Niculae, Bogdan Florin Geavlete, Camelia Diaconu, Dan Mischianu

HPV represents without any doubt one of the biggest health problems nowadys. Since the early days of its discovery by zur Hausen[1] the importance of this pathogen has risen. It is role in cervix neoplasia has been already demonstrated and steps have been made to counter this threat (vaccine). There are proofs that link this virus to other ano-genital neoplasia (here we include the penis, vulva, ano-rectal region and later the laryngeal neoplasia). [...]

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