The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

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Tuesday, May 23 2017 @ 05:47 EEST

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The Vasopressin System in Metabolic Syndrome and Insulin Resistance - a Mini-Review

2016-03

Madalina Vintila, Mihail Coculescu, Florin Grigorescu, Catalina Poiana

Metabolic syndrome (MetS), type 2 diabetes, and consequent cardiovascular complications are serious healthcare problems worldwide [1,2]. The prevalence of MetS or its components around the world is variable in different ethnic populations [3,4], and this can be explained by interactions between susceptibility genes specifically expressed in certain ethnic groups and environmental factors [5]. Nonetheless, the number of people aff ected by these conditions is continuously increasing at a global level [4,6] and along with it the mortality and morbidity of populations [7,8]. Cardiovascular disease (CVD) is the main cause of mortality in people suffering from MetS and/or diabetes [9]. The research in this field is ongoing, in the attempt to elucidate the pathophysiological mechanisms and pathways involved in MetS, and to find reliable biomarkers for diagnosis and disease prognosis, as well as therapeutic targets. [...]

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Review on Non-Invasive Diagnosis of Pancreatic Cancer

2016-03

Iulia Petre, Coralia Bleotu, Madalina Ilie, Radu Tincu, Bogdan Popa, Gabriel Constantinescu

The pancreatic cancer has the worst prognosis among gastrointestinal cancers with a mortality rate close to incidence. The analysis on the globe carried out by GLOBOCAN in 2012 places the pancreatic cancer on the 13th place in terms of incidence and on the 8th place in terms of mortality of all cancers and in relation with digestive cancers it occupies the 6th place for both epidemiological indices [1]. [...]

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Recent Advances in the Genetics of Pheochromocytomas and Paragangliomas

2016-03

Alexandra Mirica, Ioana Anca Badarau, Radu Mirica, Sorin Paun, Catalina Poiana, Diana Loreta Paun

Pheochromocytomas (Pheos) and paragangliomas (Pgls) are rare neuroendocrine tumors, with the same embriologic origin. Based on WHO classification, chromaffin tumors of the adrenal medulla are called Pheos, whereas tumors arising from extra-adrenal chromaffi n cells, along the autonomous nervous chains, are named Pgls [1]. Furthermore, there are two types of Pgls according to their homologous nervous chain: sympathetic and parasympathetic tumors. Sympathetic Pgls are developing from the pre- and paravertebral sympathetic ganglia (ex: Pgls of the thorax, mediastinum, abdomen) and from the connective tissue within the pelvic organs (ex:urinary bladder Pgl). They release dopamine or norepinephrine (NE) because they lack phenylethanolamine N-methyltransferase (PNMT), the enzyme in charge of transforming NE into epinephrine (E), that is specific to adrenal medulla. [...]

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Osteosarcoma in Children and Adolescents - a Single Center Review of Presentation, Therapy and Outcome

2016-03

Razvan-Cosmin Petca, Stefan Gavriliu, Gheorghe Burnei

Worldwide, cancer is the second leading cause of death, following heart disease, accounting for 23% of all deaths. Although most cancers causing death are carcinomas of lung, prostate and breast, primary malignancy of the bone is ranked as the third leading cause of death in patients with cancer who are younger than 20 years [1]. [...]

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A Long Term Clinical Comparison in Cases of High Volume Benign Prostatic Obstruction - Bipolar Plasma Enucleation Versus...

2016-03

A Long Term Clinical Comparison in Cases of High Volume Benign Prostatic Obstruction - Bipolar Plasma Enucleation Versus Standard Prostatectomy

Catalin Bulai, Petrisor Geavlete, Cosmin Ene, Ovidiu Bratu, Ileana Peride, Andrei Niculae, Bogdan Geavlete

Despite the constant technological advances achieved during the past decades, large size benign prostatic hyperplasia (BPH) pathology continues to raise questions concerning the most appropriate therapeutic approach. Interestingly enough, the classical open prostatectomy still represents the standard option for this type of cases despite the substantial perioperative morbidity [1]. [...]

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