The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

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Outcome of Children with Acute Lymphoblastic Leukemia Treated with the ALL-BFM 95 Protocol during 2001-2014 at the Pediatric...

2016-03

Outcome of Children with Acute Lymphoblastic Leukemia Treated with the ALL-BFM 95 Protocol during 2001-2014 at the Pediatric Hematology Center from Tirgu-Mures

Adrienne Horvath, Zsuzsanna Erzsebet Papp, Mihaela Chincesan, Maria Despina Baghiu

Acute lymphoblastic leukemia (ALL) is responsible for 25% of all childhood cancers. The outcome has dramatically changed during the last decades, reaching an overall survival rate of approximately 80% in high-income countries and lower rates in low and middle-income countries [1-6]. Recent trials with risk stratifi cation based on biological features of leukemic cells and response to therapy report an even better survival rate of 90% [7].

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Vitamin D Levels Correlate with Wheezing and Asthma Recurrence in Children

2016-03

Marius Cornitescu, Gabriel Mircescu, Mariana Moiceanu, Eugenia Buzoianu, Vlad Plesca, Andrei Zamfirescu, Doina Anca Plesca

Vitamin D is a secosteroid with a pivotal role in the calcium and phosphate metabolism, two ions that are essential for bone mineralization, neuromuscular activity and general cell functions. Sources of vitamin D are either endogenous (production in the skin from 7-dehydrocholesterol under the influence of sunlight UV-B radiation) [1] or exogenous (dietary). The dietary forms of vitamin D are either of vegetal origin (ergocalciferol, vitamin D2) [2] or of animal origin (colecalciferol, vitamin D3) [3]. The two calciferol forms are similarly metabolized in humans, have equal bioavailability and effectiveness [4]. [...]

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Two-Dimensional Speckle Tracking Echocardiography - a Useful Non-Invasive Method in Predicting Significant Coronary Artery...

2016-03

Two-Dimensional Speckle Tracking Echocardiography - a Useful Non-Invasive Method in Predicting Significant Coronary Artery Disease in Low Risk Acute Coronary Syndrome

Roxana Onut, Monica Stoian, Sebastian Onciul, Diana Zamfir, Cristina Marinescu, Ioana Petre, Silvia Iancovici, Alexandra Paval, Alexandru Scafa, Lucian Calmac, Vlad Bataila, Maria Dorobanțu

Echocardiography is the first cardiac imaging technique used to evaluate patients presenting with acute coronary syndrome (ACS). However, in the absence of wall motion abnormalities, conventional echocardiography at rest provides little information. Patients presenting with low risk ACS usually have normal wall motion and left ventricle ejection fraction (LVEF) at rest.

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Carcinosarcoma of the Uterine Corpus - a Case Report and Brief Review of the Literature

2016-02

Tiberiu Augustin Georgescu, Monica Cirstoiu, Florin Catalin Cirstoiu, Mariana Costache, Anca Lazaroiu, Adrian Dumitru, Maria Sajin

Malignant Mixed Müllerian Tumors (MMMT) also referred to as carcinosarcomas are very rare and extremely aggressive tumors of the uterine corpus accounting for less than 1% of all gynecologic malignancies, 2-5% of all uterine malignancies and more than 15% of all uterine cancer associated deaths [1]. They occur almost exclusively in post-menopausal women, but have been reported in premenopausal women as well, including young girls [2]. Carcinosarcomas have poor prognostic outcome, regardless of stage at diagnosis. The five-year survival rate ranges between 5% and 40% for patients with tumors of all stages [2-5] and does not improve significantly even with the introduction of increasingly aggressive adjuvant therapies.

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A Rare Tumor - Primary Leiomyosarcoma of Pulmonary Artery. Case Presentation

2016-02

Laura Rebegea, Dorel Firescu, Mihaela Dumitru, Alina Mihaela Calin, Rodica Anghel

Pulmonary artery sarcomas (PA) are uncommon; the first case was documented in 1923 by Mandel Staam. Leiomyosarcoma, fibrosarcoma and rhabdomyosarcoma are the most often histologically confirmed incidences. PA tumor is frequently misinterpreted as thrombo-embolism, as its correct diagnosis is difficult. Magnetic Resonance Imaging (MRI) is superior in providing an accurate diagnosis. Surgery is the only therapeutic strategy which may extend life expectancy. The survival rate in the absence of surgical care is of 1.5 months, survival for 5 years - 6%. In most cases, death occurs by heart failure, and rarely by distant metastases. [...]

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