The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

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Monday, October 23 2017 @ 05:29 EEST

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Pharmacodynamics of Serotonin. Emphasis on 5HT-3 Antagonists and SSRI Medication (II)

2017-01

Mihnea Costescu, Horia Paunescu, Sorina Vasile, Aurelian Zugravu, Oana Andreia Coman, Ion Fulga

5-HT4 receptors are a G-protein-coupled family of re-ceptors coupled with Gs protein that stimulates the pro-duction of the intracellular signaling molecule cAMP. It has two isoforms (5-HT4S and 5-HT4L), differing in the length and sequence of their C-termini[1]. 5-HT4 are present both in the central nervous system and peripheral tissues; in the brain, are found mostly in basal ganglia and the hippocampus[2]. In the periphery, 5HT4 play an important role in the functioning of gastrointestinal tract, urinary bladder, heart and adrenal gland. Gastrointestinal 5-HT4 receptors potentiate peristalsis, and electrolyte secretion. In the urinary bladder, acti-vation of 5-HT4 receptors modulates cholinergic and purinergic transmission. Stimulation of atrial 5-HT4 receptors produces tachycardia and arrhythmias. In the adrenal gland, activation of 5-HT4 receptors releases cortisol, aldosterone and corticosterone[3]. [...]

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HPV and Bladder Cancer - Is There a Connection?

2017-01

Dan Arsenie Spinu, Ovidiu Gabriel Bratu, Dragos Radu Marcu, Andrei Niculae, Bogdan Florin Geavlete, Camelia Diaconu, Dan Mischianu

HPV represents without any doubt one of the biggest health problems nowadys. Since the early days of its discovery by zur Hausen[1] the importance of this pathogen has risen. It is role in cervix neoplasia has been already demonstrated and steps have been made to counter this threat (vaccine). There are proofs that link this virus to other ano-genital neoplasia (here we include the penis, vulva, ano-rectal region and later the laryngeal neoplasia). [...]

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An Unfortunately Surprise of a Renal Cystic Mass - Case Presentation

2016-04

Ovidiu Bratu, Dragos Marcu, Dan Spinu, Ioana Oprea, Ileana Peride, Dan Liviu Dorel Mischianu

Cystic renal masses represents a pathology that may rise diagnosis and management difficulties. The differential diagnosis of large renal cystic masses should be made with normal renal cysts, hydronephrosis, renal abscess, renal hematoma, morpho-functional demaged kidney or with a renal tumor with necrosis and abscess. [...]

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Upper GI Bleeding with Hemorrhagic Shock Caused by Infectious Esophagitis

2016-04

Daniela Tabacelia, Madalina Ilie, Gabriel Constantinescu, Radu Tincu, Bogdan Popa, Raluca Stanciulescu, Valentin Enache, Dragos Ene

CMV infection in healthy hosts is generally asymptomatic, producing a latent infection with antibodies persisting for months or even years after the recovery. In the population at risk, CMV infection is one of the most frequent opportunistic infection. The most frequent GI manifestation of CMV infection is colitis followed by esophagitis although it can affect all organs. CMV esophagitis has been reported in immunocompromised hosts by conditions like organ transplantation, bone marrow transplantation, in patients with HIV infection and AIDS or other debilitating diseases. [...]

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Comparison of Osteosynthesis Using Plates and Screws Versus Kirschner Wire Fixation for Unstable Metacarpal Fractures: a...

2016-04

Comparison of Osteosynthesis Using Plates and Screws Versus Kirschner Wire Fixation for Unstable Metacarpal Fractures: a Retrospective Clinical Study

Tiberiu Paul Neagu, Ion Cocolos, Mirela Tiglis, Ioana Cristina Grintescu, Mazen Elfarra, Ioana Teona Sebe, Cristian Radu Jecan, Ioan Lascar

Hand surgery is considered to be the biggest challenge for every plastic surgeon. The social value of the hand is appreciated by any individual, butmostly by plastic surgeons which are, par excellence, hand-working persons. When a hand injury is treated you must consider the Hippocratic concept which states that "healing is a matter of time but it is sometimes also a matter of opportunity". The hand forms a functional unit with the forearm which is a high-precision machine, with multiples levers, who has tactile intelligence that ensure its auto-mechanism, being able to grab and maintain, in any spatial position, large and small tools invented by human genius. The hand is both a motor and sensory organ, and in terms of society,it is an organ of defense, an organ of creation and expression. This is why hand surgery is very important, both in medical and social terms, and any research in this domain has one purpose: improving the treatment of hand injuriesin order to obtain functional results closer to the genetic scale of the divine creation. The purpose of this study was to assess different osteosynthesis techniques in order to establish which one is better in matters of functional results. [...]

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