The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

Welcome to ModernMedicine
Thursday, May 24 2018 @ 08:03 EEST

View Printable Version

Study Regarding the Distribution and Degree of Dysplasia of Colonic Polyps

2014-03

M. Ifrim, C. Toth, C. Precup

There are worldwide standardization attempts, through therapeutic guidelines of colon cancer screenings. For a screening to be effective, it must involve a more complex understanding of risk factors, finding effective methods and most importantly to applied en masse at an acceptable cost.

In this study I tried to present the situation regarding colon cancer screening in at risk patients in Arad county.

View full article
View Printable Version

Split-thickness Skin Grafting in the Treatment of Surgically Operated Diabetic Foot. A Retrospective 2-Year Study (2010-2011)

2014-03

Mihaela Vilcu, E. Catrina, T. Pătrașcu, Z. Filipovski, I. Brezean

Diabetes mellitus is a major health problem with significant impact on the quality of life, due to both its complications and comorbidities and due to the costs it generates. There is widespread agreement that the incidence of the disease has increased over the last years, both due to better population monitoring and improvements in diagnosing methods.

Thus, the number of cases of diabetes mellitus worldwide was 382 million in 2013 and the number is rising; there are 75 million cases of diabetes mellitus which go undiagnosed, as the majority of diabetic patients are discovered only when complications set in. (1)

View full article
View Printable Version

Dispersion of Ventricular Repolarization in Relation to Blood Pressure Values in Essential Hypertension

2014-03

Ana Ciobanu, Andreea Simona Hodorogea, Mădălina Ababei, Gabriela Silvia Gheorghe, Adriana Mihaela Ilieșiu, Gabriela Uscoiu, Camelia Nicolae, I.T. Nanea

Hypertension associates with sudden cardiac death, its relationship with ventricular arrhythmias being demonstrated by numerous studies (1). Multiple mechanisms were proposed in order to explain this association, involving both structural and electrophysiological myocardial changes. The electrical ventricular remodeling includes non-uniform prolongation of action potential and duration heterogeneity of refractory periods and conduction velocities of adjacent myocardial areas. All of these changes are referred to as increased dispersion of ventricular repolarization.

As cellular basis for this important mechanism of arrhythmogenesis, 3 myocardial cell types were described, with distinct electrophysiological properties: epicardial, endocardial and midmiocardial M cells (2). Differences between their repolarization periods have as an electrocardiographic correspondence changes in T wave features (2). Subsequently, several non-invasive electrocardiographic (ECG) parameters were proposed for quantification of the repolarization dispersion such as QT interval duration, QT dispersion (QTd), T wave microalternans, and more recently, T peak - T end interval (Tpe), T peak - T end/QT ratio (Tpe/QT) and T peak - T end interval dispersion (dTpe).

View full article
View Printable Version

LIVER FUNCTION TESTS ANOMALIES IN PATIENTS WITH CHRONIC HEART FAILURE

2014-03

Camelia C. Diaconu, Alice Bălăceanu, Daniela Bartoș

Chronic heart failure is a major public health problem, with increasing prevalence due to population aging and increased survival of cardiovascular patients. Chronic heart failure is a clinical syndrome characterized by a variety of effects on other organs and systems. Occasionally, patients with chronic heart failure may present with signs and symptoms of a noncardiac disorder, such as hepatic dysfunction. The main pathophysiologic mechanism involved in hepatic dysfunction of patients with heart failure is either passive congestion due to increased filling pressures or low cardiac output and the consequences of impaired perfusion. Passive hepatic congestion may lead to increase of liver enzymes and total bilirubin. Right ventricular dysfunction can be associated with severe hepatic congestion, which can be asymptomatic and revealed only by abnormal liver function tests. When hemodynamic abnormalities are prolonged, the hepatic function is further altered, with impaired coagulation tests and decreased albumin synthesis. Morphologically, the liver becomes fibrotic and ultimately cardiac cirrhosis appears. Decreased perfusion from low cardiac output may be associated with hepatocellular necrosis and increased serum aminotransferases. Acute cardiogenic liver injury appears in severe systemic hypotension due to exacerbation of heart failure; the level of aminotransferases increases, as well as lactic dehydrogenase and prothrombin time.

The aim of our study was to evaluate the frequency and the importance of liver function tests abnormalities in a group of patients with chronic heart failure, as well as the prognostic value of these liver tests.

View full article
First | Previous | 123 | Next | Last