The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

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Tuesday, July 17 2018 @ 04:30 EEST

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Cytostatic Therapy on Tumor Bearing Mice: Biochemical and Hematological Aspects

2016-01Laurentiu Anghelache, Bogdan Marinescu, Gheorghita Isvoranu, Dan Cringanu, Andrei Niculae, Ovidiu Bratu

The animals used in research as experimental models are selected for genetic, anatomical and physiological similarities. Rodents are the most representative experimental model; to emphasize this statement mice are used due to human DNA similarity (According to The Jackson Laboratory over 95% of the mouse genome is similar to our own, making mouse genetic research particularly applicable to human disease), simplicity in procurement, handling and short lifespan [1-3].

The purpose of this information is to help investigators who pursue an economical and efficient research that still allows the achievement of the study goals [4-7] [...]

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Urinary Leukotriene Level in Children with Asthma

2016-01Eugenia Buzoianu, Mariana Moiceanu, Oana Virban, Varvara Toma, Felicia Cora, Aurora Craiciu, Vlad Plesca, Ioana Grapinoiu, Doina Anca Plesca

Asthma is a chronic inflammatory disease of the airways and it represents a major cause of morbidity and mortality, having a rising incidence in the entire world (1).

The physiopathological features of asthma are chronic inflammation of the bronchial mucosa and bronchial hyperreactivity which is expressed as bronchoconstriction in response to various triggers (2) [...]

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Blood Lead Levels and Oxidative Stress

2016-01Radu Ciprian Tincu, Dana Tomescu, Laurentiu Coman, Radu Alexandru Macovei

Environmental lead sources are represented by air, soil, food, water. Lead distribution in the environment continues to be a worrying public health issue considering its potential cumulative effects in the body due to various routes of exposure. Once exposed to lead, individuals have persistent elevated blood levels because of redistribution from bones sanctuaries, even years after cessation of exposure. Oxidative stress seems to play an important part regarding lead adverse effects, because the metal is responsible for reactive oxygen species (ROS) production and it also might inhibit antioxidants levels [...]

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Obesity-Related Comorbidities: One Actress, Multiple Scenes

2016-01Camelia C. Diaconu, Giorgiana Dediu

Obesity is a chronic disease, with increasing incidence and prevalence in Europe and United States, not only in adults, but in children and adolescents too. Worldwide, mean BMI is increasing, 36.9% of men and 38% of women being estimated as having a BMI ≥25 Kg/m2 (1,2).

In 1997, the World Health Organization declared obesity as a major public health problem and a global epidemic [...]

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Left Atrial Structural and Functional Remodeling in Hypertensives - An Echocardioghraphic Study

2016-01Ioana Petre, Adriana Alexandrescu, Silvia Iancovici, Sebastian Onciul, Oana Florentina Tautu, Maria Dorobantu

Arterial hypertension (HTN) is a common cardiovascular pathology that usually complicates with cardiac dysfunction. HTN alters atrial dynamics significantly, leading to left atrial (LA) morphological and functional abnormalities.

Echocardiography proved to be an adequate method of evaluation of LA remodeling, by its means of assessing with accuracy LA size, volumes and its multiple functions [...]

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