The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

Welcome to ModernMedicine
Wednesday, November 21 2018 @ 12:21 EET

View Printable Version

Carcinosarcoma of the Uterine Corpus - a Case Report and Brief Review of the Literature

2016-02

Tiberiu Augustin Georgescu, Monica Cirstoiu, Florin Catalin Cirstoiu, Mariana Costache, Anca Lazaroiu, Adrian Dumitru, Maria Sajin

Malignant Mixed Müllerian Tumors (MMMT) also referred to as carcinosarcomas are very rare and extremely aggressive tumors of the uterine corpus accounting for less than 1% of all gynecologic malignancies, 2-5% of all uterine malignancies and more than 15% of all uterine cancer associated deaths [1]. They occur almost exclusively in post-menopausal women, but have been reported in premenopausal women as well, including young girls [2]. Carcinosarcomas have poor prognostic outcome, regardless of stage at diagnosis. The five-year survival rate ranges between 5% and 40% for patients with tumors of all stages [2-5] and does not improve significantly even with the introduction of increasingly aggressive adjuvant therapies.

View full article
View Printable Version

A Rare Tumor - Primary Leiomyosarcoma of Pulmonary Artery. Case Presentation

2016-02

Laura Rebegea, Dorel Firescu, Mihaela Dumitru, Alina Mihaela Calin, Rodica Anghel

Pulmonary artery sarcomas (PA) are uncommon; the first case was documented in 1923 by Mandel Staam. Leiomyosarcoma, fibrosarcoma and rhabdomyosarcoma are the most often histologically confirmed incidences. PA tumor is frequently misinterpreted as thrombo-embolism, as its correct diagnosis is difficult. Magnetic Resonance Imaging (MRI) is superior in providing an accurate diagnosis. Surgery is the only therapeutic strategy which may extend life expectancy. The survival rate in the absence of surgical care is of 1.5 months, survival for 5 years - 6%. In most cases, death occurs by heart failure, and rarely by distant metastases. [...]

View full article
View Printable Version

Urinary System Spontaneous Rupture - an Urological Emergency

2016-02

Dragos Marcu, Ovidiu Bratu, Dan Spinu, Robert Popescu, Agnes Ciuca, Maria Galaman, Ioana Oprea, Dan Mischianu

Spontaneous rupture of the urinary collecting system is a rare urologic pathology, but due to the severity of its possible complications, it represents an urological emergency which requires adequate urgent treatment. [...]

View full article
View Printable Version

The Role of the Extraperitoneal Drainage in the Corrective Surgery of the Intraoperative-Discovered Accidental Lesions of the...

2016-02

The Role of the Extraperitoneal Drainage in the Corrective Surgery of the Intraoperative-Discovered Accidental Lesions of the Common Bile Duct

Alec Cosmin Moldovan, Florin Dan Ungureanu, Vladimir Belis

Up to date, one of the most well-known and used classification for defining bile duct lesions belongs to Bismuth [1] and was later assumed by laparoscopic surgery as well. In this classification, the author is taking into consideration the remaining intact bile duct length and does not include bile collections that may arise from a bilistasis defect in the cystic duct or the liver bed, nor the lateral solutions of continuity of the main bile duct and right hepatic duct. These kind of iatrogenic injuries were initially reported only after classic cholecystectomy, and this is why, later, with the development and rise of the laparoscopic approach, Strasberg and Soper [2] modified this classification of accidental injuries inclu-ding these as well. [...]

View full article
View Printable Version

Pharmacodynamics of Serotonin. Emphasis on 5HT-3 Antagonists and SSRI Medication (I)

2016-02

Mihnea Costescu, Horia Paunescu, Sorina Vasile, Aurelian Zugravu, Oana Andreia Coman, Ion Fulga

Serotonin (5-hydroxytryptamine or 5-HT)is a mo-noamine neurotransmitter involved in regulating and modulating physiological and behavioral processes [1]. Serotonin also plays an important role in the functio-ning of enteric nervous system [2]. [...]

View full article
View Printable Version

Genome-Wide Association Scan for Variants Associated with Early-Onset Prostate Cancer in Romania

2016-02

George Daniel Radavoi, Paul Daniel Iordache, Viorica Radoi, Radu Ioan Ursu, Stefan Rascu, Cristian Sima, Marian Vargau, Bogdan Cheorpeaca, Dan Mischianu

Prostate cancer incidence varies more than 25-fold worldwide, largely due to the widespread practice of prostate specific antigen (PSA) testing and subsequent biopsy [1]. It is the second most frequently diagnosed cancer of men (914.000 new cases per year, accounting for 13.8% of total cancer cases) and the 5th most common cancer overall worldwide. The incidence is expected to grow to 1.7 million new cases and 499.000 deaths by 2030, mainly due to the growth and aging of the global population [2]. [...]

View full article
View Printable Version

Blood Pressure Control and Quality of Life in Hypertensive Patients Treated with Amlodipine/Valsartan Fixed Dose Combination...

2016-02

Blood Pressure Control and Quality of Life in Hypertensive Patients Treated with Amlodipine/Valsartan Fixed Dose Combination - IMPROVE Study Results

Oana Tautu, Irina Antohi, Viorica Pantelimonescu, Violeta Macovei, Elena Cristina Popescu, A. Stoica, Daniela Selaru, Diana Matura, Daniela Pantilie, Maria Dorobantu

High blood pressure is the world’s most common cause of death, estimated to affect at 4 out of 10 Romanian adults [1-3]. Despite the availability of a wide range of antihyper-tensive drugs, about 70% of treatment hypertensive pa-tients fail to achieve the blood pressure target of less than 140/90 mmHg recommended by the current guidelines [4,5]. In Romania, less than one quarter of treated hypertensive adults have a controlled blood pressure (less than 140/90 mmHg) [1-3,6,7]. [...]

View full article
View Printable Version

Is Vascularized Composite Allotransplantation a Suitable Reconstructive Option for Extensive Defects in Burned Patients?...

2016-02

Is Vascularized Composite Allotransplantation a Suitable Reconstructive Option for Extensive Defects in Burned Patients? Clinical and Immunological Evaluation Protocol

Andreea Grosu-Bularda, Serban Arghir Popescu, Razvan Teodoreanu, Liviu Cojocaru, Luana Lazarescu, Ioan Lascar

Vascularized composite tissue allotransplantation (VCA) is a recent reconstructive entity that bases on the restoration of deformity by the allotransplantation of a vascularised tissue unit with more components (skin, muscle, bone, cartilage, bone marrow, tendon, nerve). Since the field emerged with the first hand transplant performed in France in 1998, VCA showed a huge potential in replacement of extensive tissue defects and disfigurements (after burns, severe high energy trauma like gunshots, congenital facial malformations), offering a viable treatment option for injuries that involve multiple layers of functional tissue, impossible to repair using conventional surgical techniques, permitting restoration of extensive defects in just one stage procedure with good functional and aesthetic results. A significant number of those procedures have been reported worldwide for various anatomic locations including upper and lower extremities, face, tongue, trachea, larynx, abdominal wall, uterus and penis. These procedures are offered for quality of life and functional indications rather than life-saving indications [1-7]. [...]

View full article
View Printable Version

Can Complementary Feeding Patterns Influence Rapid Weight Gain in Infancy?

2016-02

Iulia Florentina Tincu, Cristina Becheanu, Daniela Păcurar, Radu Ciprian Tincu, Laurentiu Coman, Dumitru Oraseanu

Current knowledge based on large randomized con-trolled trials documented so far that early protein intake from milk products, in the first six months of life, is associated with various changes in later outcomes regarding body weight or body composition [1,2]. Beyond the exclusive milk nutrition period, complementary fe-eding practices are less investigated in terms of obesity appearance [3]. Macronutrients supply in early life, such as carbohydrates and fats, do not seem to be implicated in later childhood obesity [4], whereas protein supply is much more studied in the present [5]. Due to rapid weight gain and body size evolution in first 3 years of life, nutritional requirements are high, but exceeding some normal ranges leads to future disturbances. [...]

View full article
View Printable Version

The Analgesic Effect of 5-fluorouracil in Mice

2016-02

Smaranda Stoleru, Horia Paunescu, Aurelian Zugravu, Sorina Vasile, Oana Andreia Coman, Ion Fulga

Pain is defined by IASP (International Association for the Study of Pain) as an unpleasant sensorial and emotional feeling which is produced by an actual or potential tissue injury. Chronic pain management is currently a major public health challenge throughout the world, especially for patients with oncologic disorders. Data show that up to 90 percent of cancer patients suffer from pain during the course of their illness and 50-80 percent receive an inadequate pain management. [...]

View full article
View Printable Version

Burden of Clostridium Difficile Infection in Inflammatory Bowel Disease

2016-02

Alina Constantin, Madalina Ilie, Daniela Tabacelia, Bogdan Popa, Gabriel Constantinescu, Radu Tincu, Radu Alexandru Macovei

Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and Ulcerative Colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract. There is epidemiologic evidence that in patients with IBD, Clostridium difficile infection (CDI) occurs more frequently than in the general population and that these rates have been increasing over the past several decades. [...]

View full article
View Printable Version

The Role of Capsule Endoscopy in Obscure GI Bleeding: Experience of a Tertiary Center in Romania

2016-02

Lucian Negreanu, Ana Filimon, Ana Stemate, Theodor Voiosu, Bogdan Mateescu

Obscure gastrointestinal bleeding OGIB represents about 5% of those patients with gastrointestinal bleeding of any type. It is defined as persistent or recurrent bleeding of unknown origin (i.e., recurrent or persistent iron-deficiency anemia, positive fecal occult blood test, or visible bleeding) with a negative upper and/or lower gastrointestinal endoscopy. [...]

View full article
View Printable Version

Implications of Interleukins in Liver Fibrosis and Sustained Virological Response in Patients with Viral Hepatitis C

2016-02

Alexandra Floriana Rosu, Ovidiu Mircea Zlatian, Viorel Biciusca, Lucica Rosu, Rui Tato Marinho, Tudorel Ciurea

Hepatitis C virus (HCV) is a major cause of progressive hepatic disease with a high impact on human health worldwide. Patients with chronic hepatitis C have an increased risk of complications with need of hospitali-zation for different associated pathology. Liver fibrosis is correlated with high morbidity and mortality. Liver cirrhosis is frequently associated with anemia caused by gastrointestinal hemorrhage from esophageal varices or from angiodysplasia of the antrum. [...]

View full article
View Printable Version

Secrets Behind a Successful Career

2016-02

Stefan Hell

"Today, now co-responsible for the new generations of scientists, I often wonder whether the way in which science is organized sufficiently encourages young re-searchers to pursue unusual research topics." [...]

View full article