The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

Welcome to ModernMedicine
Tuesday, July 17 2018 @ 04:41 EEST

View Printable Version

Genome-Wide Association Scan for Variants Associated with Early-Onset Prostate Cancer in Romania

2016-02

George Daniel Radavoi, Paul Daniel Iordache, Viorica Radoi, Radu Ioan Ursu, Stefan Rascu, Cristian Sima, Marian Vargau, Bogdan Cheorpeaca, Dan Mischianu

Prostate cancer incidence varies more than 25-fold worldwide, largely due to the widespread practice of prostate specific antigen (PSA) testing and subsequent biopsy [1]. It is the second most frequently diagnosed cancer of men (914.000 new cases per year, accounting for 13.8% of total cancer cases) and the 5th most common cancer overall worldwide. The incidence is expected to grow to 1.7 million new cases and 499.000 deaths by 2030, mainly due to the growth and aging of the global population [2]. [...]

View full article
View Printable Version

Blood Pressure Control and Quality of Life in Hypertensive Patients Treated with Amlodipine/Valsartan Fixed Dose Combination...

2016-02

Blood Pressure Control and Quality of Life in Hypertensive Patients Treated with Amlodipine/Valsartan Fixed Dose Combination - IMPROVE Study Results

Oana Tautu, Irina Antohi, Viorica Pantelimonescu, Violeta Macovei, Elena Cristina Popescu, A. Stoica, Daniela Selaru, Diana Matura, Daniela Pantilie, Maria Dorobantu

High blood pressure is the world’s most common cause of death, estimated to affect at 4 out of 10 Romanian adults [1-3]. Despite the availability of a wide range of antihyper-tensive drugs, about 70% of treatment hypertensive pa-tients fail to achieve the blood pressure target of less than 140/90 mmHg recommended by the current guidelines [4,5]. In Romania, less than one quarter of treated hypertensive adults have a controlled blood pressure (less than 140/90 mmHg) [1-3,6,7]. [...]

View full article
View Printable Version

Is Vascularized Composite Allotransplantation a Suitable Reconstructive Option for Extensive Defects in Burned Patients?...

2016-02

Is Vascularized Composite Allotransplantation a Suitable Reconstructive Option for Extensive Defects in Burned Patients? Clinical and Immunological Evaluation Protocol

Andreea Grosu-Bularda, Serban Arghir Popescu, Razvan Teodoreanu, Liviu Cojocaru, Luana Lazarescu, Ioan Lascar

Vascularized composite tissue allotransplantation (VCA) is a recent reconstructive entity that bases on the restoration of deformity by the allotransplantation of a vascularised tissue unit with more components (skin, muscle, bone, cartilage, bone marrow, tendon, nerve). Since the field emerged with the first hand transplant performed in France in 1998, VCA showed a huge potential in replacement of extensive tissue defects and disfigurements (after burns, severe high energy trauma like gunshots, congenital facial malformations), offering a viable treatment option for injuries that involve multiple layers of functional tissue, impossible to repair using conventional surgical techniques, permitting restoration of extensive defects in just one stage procedure with good functional and aesthetic results. A significant number of those procedures have been reported worldwide for various anatomic locations including upper and lower extremities, face, tongue, trachea, larynx, abdominal wall, uterus and penis. These procedures are offered for quality of life and functional indications rather than life-saving indications [1-7]. [...]

View full article
View Printable Version

Can Complementary Feeding Patterns Influence Rapid Weight Gain in Infancy?

2016-02

Iulia Florentina Tincu, Cristina Becheanu, Daniela Păcurar, Radu Ciprian Tincu, Laurentiu Coman, Dumitru Oraseanu

Current knowledge based on large randomized con-trolled trials documented so far that early protein intake from milk products, in the first six months of life, is associated with various changes in later outcomes regarding body weight or body composition [1,2]. Beyond the exclusive milk nutrition period, complementary fe-eding practices are less investigated in terms of obesity appearance [3]. Macronutrients supply in early life, such as carbohydrates and fats, do not seem to be implicated in later childhood obesity [4], whereas protein supply is much more studied in the present [5]. Due to rapid weight gain and body size evolution in first 3 years of life, nutritional requirements are high, but exceeding some normal ranges leads to future disturbances. [...]

View full article
View Printable Version

The Analgesic Effect of 5-fluorouracil in Mice

2016-02

Smaranda Stoleru, Horia Paunescu, Aurelian Zugravu, Sorina Vasile, Oana Andreia Coman, Ion Fulga

Pain is defined by IASP (International Association for the Study of Pain) as an unpleasant sensorial and emotional feeling which is produced by an actual or potential tissue injury. Chronic pain management is currently a major public health challenge throughout the world, especially for patients with oncologic disorders. Data show that up to 90 percent of cancer patients suffer from pain during the course of their illness and 50-80 percent receive an inadequate pain management. [...]

View full article