The Journal of Bucharest College of Physicians and the Romanian Academy of Medical Sciences

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Monday, December 10 2018 @ 07:11 EET

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A Case of Neurodegenerative Langerhans Cell Histiocytosis

2018-03

Ana-Maria Petrica, Nicolae-Ovidiu Gavrilovici, Doina Paula Pruteanu, Roxana Petean, Emilie Mihut, Rodica Cosnarovici, Elena Diana Olteanu

https://doi.org/10.31689/rmm.2018.25.3.181

Langerhans cell histiocytosis (LCH) is a myeloproliferative neoplasm of pathologic dendritic cells (DC). This is supported by the clonality of these cells, the recurrent mutations in BRAF-V600E and other MAPK pathway genes, the identification of the BRAF-V600E mutation in hematopoietic stem cells and myeloid precursors in patients with high-risk LCH[1]. An estimated 4-5 per million patients are affected each year, from the neonatal period to adulthood, although it appears to be more common in children of 0-15 years[2,3]. [...]

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Another Approach of Resistant Hypertension: What to Do When the Pharmacological Treatment Fails?

2018-03

Silvia Matilda Astefanei, Alina-Elena Cristea, Ana-Maria Zaharie, Oana-Claudia Deleanu

https://doi.org/10.31689/rmm.2018.25.3.175

Obstructive sleep apnea (OSA) is an important risk factor for elevated blood pressure (BP), especially in patients with resistant hypertension (RHT)[1]. HT physiopathology in OSA patients involves aspects such as secondary sympathetic hyper reactivity because of intermittent hypoxia, decreased barometric sensitivity, endothelial dysfunction. [...]

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X-linked Lissencephaly: a Smooth Brain and a Rough Journey for a 15-Year-Old-Patient

2018-03

Marius-Cristian Zaharia, Diana Anamaria Epure, Ioana Streata, Raluca Ioana Teleanu

https://doi.org/10.31689/rmm.2018.25.3.171

The cerebral cortex shows a precise layering of multiple neuronal types with distinct form and function, essential for the cognitive functions that define us as humans. Remarkably, cortical neurons are not formed in the cortex itself but in specialized proliferative regions deep in the brain, so that postmitotic neurons must migrate as far as 1000 cell body-lenghts to reach their final destination[1]. [...]

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Aggressive Nasal Type Extranodal Natural killer/T-cell Lymphoma Presenting as Refractory Granulomatosis with Polyangiitis...

2018-03

Aggressive Nasal Type Extranodal Natural killer/T-cell Lymphoma Presenting as Refractory Granulomatosis with Polyangiitis (Wegener’s Granulomatosis)

Andreea-Alexandra Aldea, Anca Bojan, Laura Muntean, Simona Rednic

https://doi.org/10.31689/rmm.2018.25.3.163

We present a rare case of nasal type extranodal NK/T-cell lymphoma mimicking granulomatosis with polyangiitis (GPA), in order to highlight the difficulties in the differential diagnosis of destructing nasal lesions. Extranodal NK/T-cell lymphoma, nasal type is a rare type of non-Hodgkin’s lymphoma, often associated with Epstein-Barr virus (EBV) infection, characterised by destructive lesions arising in the naso-sinusal tract and progressively invading the midfacial bones. [...]

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Unusual Combination of Posterior Femoral Head Dislocation and Ipsilateral Intertrochanteric Open Fracture: Case Report

2018-03

Ion Cocolos, Tiberiu Paul Neagu, Andrei Ursache, Ioan Cristescu, Adina Ghemigian, Andra Maria Cocolos, Camelia Cristina Diaconu, Ovidiu Gabriel Bratu, Mirela Tiglis, Olivera Lupescu

https://doi.org/10.31689/rmm.2018.25.3.159

The combination of posterior femoral head dislocation with ipsilateral intertrochanteric fracture is an extremely rare occurrence, therefore, few reports exist. The posterior femoral head dislocation is an injury most common encountered in road traffic accident (dash-board) and may associate various types of acetabular, femoral head or femoral neck fractures[1-3] but almost never an intertrochanteric fracture. [...]

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Results in Breast Reconstruction - Retrospective Study

2018-03

Iulia Gabriela Stan, Cristian Radu Jecan, Ovidiu Stefanescu, Laura Raducu, Tiberiu Paul Neagu, Ioan Lascar

https://doi.org/10.31689/rmm.2018.25.3.149

In the last century, the breast reconstruction after mastectomy has become an important element of the multicentric treatment of the patients suffering from breast cancer. Breast reconstruction was initially developed to reduce the complications of mastectomy and the deformations of the thoracic wall. Currently, it is known the fact that reconstruction can improve the psychosocial state and the quality of life of the patients with breast cancer[1]. [...]

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Symptoms of Attention Deficit, Hyperactivity and Impulsivity in a Sample of Personality Disorder Patients

2018-03

Laura Aelenei, Dan Prelipceanu

https://doi.org/10.31689/rmm.2018.25.3.137

ADHD and personality disorders are known to have clinical presentations that sometimes share different symptoms. Their characteristics are pervasive, relatively stable over the years. This study tries to determine the prevalence of attention deficit and hyperactivity/im-pulsivity symptoms in a population of individuals with a personality disorder. [...]

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Endometriosis-Associated Infertility

2018-03

Elena-Silvia Nada, Lacramioara Brinduse, Ovidiu Bratu, Dragos Marcu, Elvira Bratila

https://doi.org/10.31689/rmm.2018.25.3.131

Endometriosis is definined as the presence of endometrial-like tissue outside the uterine cavity and it presumably affects 10-15% of reproductive aged women. The prevalence of endometriosis appears to be higher in women in Philippines, Indian, Japanese and Korean origin[1]. Clinical manifestations depend upon the site where the ectopic endometrial tissue is located and include dysmenorrhea, dyspareunia, chronic pelvic pain, infertility, but the possibility of being asymptomatic exists. [...]

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Management of Hypertension in the Elderly by Modern Methods

2018-03

Sorina Maria Aurelian, Ruxandra Dascalescu, Andreea Zamfirescu, Ana Capisizu

https://doi.org/10.31689/rmm.2018.25.3.125

An increasing public health concern is the hypertensi-on in the elderly (above the age of 65 years)[1], which is under-recognized as a major contributor to premature disability and institutionalization[2]. Numerical increase in older people and consequently the consumption of drugs, associated with morpho-functional changes of the old body, bring the elderly in relationship with drugs in different position than young adults. [...]

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Update on Rehabilitation Protocol Following ACL Reconstruction

2018-03

Gavril Lucian Gheorghievici, Adriana Sarah Nica, Brindusa Mitoiu, Delia Clantau, Emil Haritinian, Cristian Ioan Stoica

https://doi.org/10.31689/rmm.2018.25.3.117

Anterior cruciate ligament lessions represent one of the most frequently met injuries of the knee, with an increasing incidence depending on the statistics, most of them occuring in athletes or young adults[1-5]. The re-construction of the anterior cruciate ligament can be obtained by using different surgical procedures and varies according to the graft material that is used. The outcomes after ACL reconstruction is depended on both surgical and rehabilitation factors[6,7]. [...]

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Methods of Transvaginal Ultrasound Examination in Endometriosis

2018-03

Alexandra Bruja, Lacramioara Brinduse, Ovidiu Bratu, Camelia Diaconu, Elvira Bratila

https://doi.org/10.31689/rmm.2018.25.3.111

"Endometriosis is a chronic, hormone-dependent condition with a nonspecific clinical picture, including chronic pelvic pain, a disturbing symptom that causes the patient to seek specialist medical advice"[1]. It is a chronic, often progressive, condition that affects women of reproductive age in a proportion of 5-10%. Despite such high prevalence, endometriosis remains an enigmatic disease with a poorly understood pathophysiology. [...]

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